Background: Deregulation of FOXO3a gene which belongs to Forkhead box O Gas Dryer (FOXO) transcription factors, can cause cancer (e.g.breast cancer).FOXO factors have important role in ubiquitination, acetylation, de-acetylation, protein-protein interactions and phosphorylation.Understanding the regulation and mechanisms of FOXO3a can lead to cance
Ion channels catalyze ionic permeation across membranes via water-filled pores.To understand how changes in intracellular magnesium concentration regulate the influx of Mg2+ into cells, we examine early events in the relaxation of Mg2+ channel CorA toward its open state using massively-repeated molecular dynamics simulations conducted either with o
Introduction.To control the concrete strength of reinforce concrete structures the shear test based on the empirical proportional dependence of concrete strength and tear force of a special Camera purpose anchor with an expanding cone is used.The absence of a physical model of a concrete deterioration when tearing strength is a sign of the defect o
In this paper discrete damage Knob Spring Clip mechanics (DDM) is used to predict inter-laminar transverse and shear damage initiation and evolution in terms of the fracture toughness of the laminate.The finite element method (FEM) is one of the most widely and most popular numerical methods for analyzing composite structures, therefore ANSYS comme